The effects of combination of Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial.
Identifieur interne : 000092 ( Main/Exploration ); précédent : 000091; suivant : 000093The effects of combination of Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial.
Auteurs : Mehdi Mesri [Iran] ; Seied Saeid Esmaeili Saber [Iran] ; Mohammadreza Godazi [Iran] ; Aboulfazl Roustaei Shirdel [Iran] ; Reza Montazer [Iran] ; Hamid Reza Koohestani [Iran] ; Nayereh Baghcheghi [Iran] ; Mahmood Karimy [Iran] ; Nemat Azizi [Iran]Source :
- Journal of complementary & integrative medicine [ 1553-3840 ] ; 2021.
Abstract
OBJECTIVES
Herbal medicines, as a treatment method, have received a great deal of attention. The effects of two herbal medicines namely
METHODS
A clinical trial with 100 suspected COVID-19 outpatients as participants was conducted. The participants were allocated randomly to two groups of 50 members. The intervention group received concurrent
RESULTS
The two groups were identical in terms of basic characteristics. Improvement level as to coughing, dyspnea, and muscle pain was higher in the intervention group (p value <0.05). There was no significant difference between the two groups in terms of the other symptoms. In addition, the hospitalization rate in the intervention and control groups were 2 and 6% respectively, which are not significantly different (p value >0.05).
CONCLUSIONS
Taking into account the efficiency and trivial side-effects of
DOI: 10.1515/jcim-2020-0283
PubMed: 33787192
Affiliations:
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wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Godazi, Mohammadreza" sort="Godazi, Mohammadreza" uniqKey="Godazi M" first="Mohammadreza" last="Godazi">Mohammadreza Godazi</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Roustaei Shirdel, Aboulfazl" sort="Roustaei Shirdel, Aboulfazl" uniqKey="Roustaei Shirdel A" first="Aboulfazl" last="Roustaei Shirdel">Aboulfazl Roustaei Shirdel</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Montazer, Reza" sort="Montazer, Reza" uniqKey="Montazer R" first="Reza" last="Montazer">Reza Montazer</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Koohestani, Hamid Reza" sort="Koohestani, Hamid Reza" uniqKey="Koohestani H" first="Hamid Reza" last="Koohestani">Hamid Reza Koohestani</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Baghcheghi, Nayereh" sort="Baghcheghi, Nayereh" uniqKey="Baghcheghi N" first="Nayereh" last="Baghcheghi">Nayereh Baghcheghi</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Karimy, Mahmood" sort="Karimy, Mahmood" uniqKey="Karimy M" first="Mahmood" last="Karimy">Mahmood Karimy</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Azizi, Nemat" sort="Azizi, Nemat" uniqKey="Azizi N" first="Nemat" last="Azizi">Nemat Azizi</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33787192</idno><idno type="pmid">33787192</idno><idno type="doi">10.1515/jcim-2020-0283</idno><idno type="wicri:Area/Main/Corpus">000161</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000161</idno><idno type="wicri:Area/Main/Curation">000161</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000161</idno><idno type="wicri:Area/Main/Exploration">000161</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effects of combination of <i>Zingiber officinale</i> and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial.</title><author><name sortKey="Mesri, Mehdi" sort="Mesri, Mehdi" uniqKey="Mesri M" first="Mehdi" last="Mesri">Mehdi Mesri</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Esmaeili Saber, Seied Saeid" sort="Esmaeili Saber, Seied Saeid" uniqKey="Esmaeili Saber S" first="Seied Saeid" last="Esmaeili Saber">Seied Saeid Esmaeili Saber</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Godazi, Mohammadreza" sort="Godazi, Mohammadreza" uniqKey="Godazi M" first="Mohammadreza" last="Godazi">Mohammadreza Godazi</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Roustaei Shirdel, Aboulfazl" sort="Roustaei Shirdel, Aboulfazl" uniqKey="Roustaei Shirdel A" first="Aboulfazl" last="Roustaei Shirdel">Aboulfazl Roustaei Shirdel</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Montazer, Reza" sort="Montazer, Reza" uniqKey="Montazer R" first="Reza" last="Montazer">Reza Montazer</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Koohestani, Hamid Reza" sort="Koohestani, Hamid Reza" uniqKey="Koohestani H" first="Hamid Reza" last="Koohestani">Hamid Reza Koohestani</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Baghcheghi, Nayereh" sort="Baghcheghi, Nayereh" uniqKey="Baghcheghi N" first="Nayereh" last="Baghcheghi">Nayereh Baghcheghi</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Karimy, Mahmood" sort="Karimy, Mahmood" uniqKey="Karimy M" first="Mahmood" last="Karimy">Mahmood Karimy</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author><author><name sortKey="Azizi, Nemat" sort="Azizi, Nemat" uniqKey="Azizi N" first="Nemat" last="Azizi">Nemat Azizi</name><affiliation wicri:level="1"><nlm:affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh</wicri:regionArea><wicri:noRegion>Saveh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of complementary & integrative medicine</title><idno type="eISSN">1553-3840</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>Herbal medicines, as a treatment method, have received a great deal of attention. The effects of two herbal medicines namely </p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A clinical trial with 100 suspected COVID-19 outpatients as participants was conducted. The participants were allocated randomly to two groups of 50 members. The intervention group received concurrent </p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The two groups were identical in terms of basic characteristics. Improvement level as to coughing, dyspnea, and muscle pain was higher in the intervention group (p value <0.05). There was no significant difference between the two groups in terms of the other symptoms. In addition, the hospitalization rate in the intervention and control groups were 2 and 6% respectively, which are not significantly different (p value >0.05).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Taking into account the efficiency and trivial side-effects of </p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33787192</PMID><DateRevised><Year>2021</Year><Month>03</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1553-3840</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year><Month>Mar</Month><Day>31</Day></PubDate></JournalIssue><Title>Journal of complementary & integrative medicine</Title><ISOAbbreviation>J Complement Integr Med</ISOAbbreviation></Journal><ArticleTitle>The effects of combination of <i>Zingiber officinale</i> and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1515/jcim-2020-0283</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Herbal medicines, as a treatment method, have received a great deal of attention. The effects of two herbal medicines namely <i>Zingiber officinale</i> and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients were examined.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A clinical trial with 100 suspected COVID-19 outpatients as participants was conducted. The participants were allocated randomly to two groups of 50 members. The intervention group received concurrent <i>Zingiber officinale</i> (Tablet Vomigone 500 mg II tds) and Echinacea (Tablet Rucoldup I tds) for seven days in addition to the standard treatment. The control group only received the standard treatment (Hydroxychloroquine). After seven days, alleviation of clinical symptoms and hospitalization rate were examined. In addition, 14 days after treatment, the hospitalization was assessed again by telephone follow up.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The two groups were identical in terms of basic characteristics. Improvement level as to coughing, dyspnea, and muscle pain was higher in the intervention group (p value <0.05). There was no significant difference between the two groups in terms of the other symptoms. In addition, the hospitalization rate in the intervention and control groups were 2 and 6% respectively, which are not significantly different (p value >0.05).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Taking into account the efficiency and trivial side-effects of <i>Zingiber officinale</i> and Echinacea, using them for alleviation and control of the clinical symptoms in COVID-19 outpatients is recommended.</AbstractText><CopyrightInformation>© 2021 Walter de Gruyter GmbH, Berlin/Boston.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mesri</LastName><ForeName>Mehdi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esmaeili Saber</LastName><ForeName>Seied Saeid</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godazi</LastName><ForeName>Mohammadreza</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roustaei Shirdel</LastName><ForeName>Aboulfazl</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montazer</LastName><ForeName>Reza</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koohestani</LastName><ForeName>Hamid Reza</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baghcheghi</LastName><ForeName>Nayereh</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karimy</LastName><ForeName>Mahmood</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azizi</LastName><ForeName>Nemat</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>03</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Complement Integr Med</MedlineTA><NlmUniqueID>101313855</NlmUniqueID><ISSNLinking>1553-3840</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Echinacea</Keyword><Keyword MajorTopicYN="N">Zingiber officinale</Keyword><Keyword MajorTopicYN="N">clinical symptoms</Keyword><Keyword MajorTopicYN="N">hospitalization rate</Keyword><Keyword MajorTopicYN="N">outpatients</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>3</Month><Day>31</Day><Hour>12</Hour><Minute>32</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>4</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33787192</ArticleId><ArticleId IdType="pii">jcim-2020-0283</ArticleId><ArticleId IdType="doi">10.1515/jcim-2020-0283</ArticleId></ArticleIdList><ReferenceList><Title>References</Title><Reference><Citation>Liu, J, Zheng, X, Tong, Q, Li, W, Wang, B, Sutter, K, et al.. 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Food Chem Toxicol 2008;46:409–20. https://doi.org/10.1016/j.fct.2007.09.085.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Mesri, Mehdi" sort="Mesri, Mehdi" uniqKey="Mesri M" first="Mehdi" last="Mesri">Mehdi Mesri</name></noRegion><name sortKey="Azizi, Nemat" sort="Azizi, Nemat" uniqKey="Azizi N" first="Nemat" last="Azizi">Nemat Azizi</name><name sortKey="Baghcheghi, Nayereh" sort="Baghcheghi, Nayereh" uniqKey="Baghcheghi N" first="Nayereh" last="Baghcheghi">Nayereh Baghcheghi</name><name sortKey="Esmaeili Saber, Seied Saeid" sort="Esmaeili Saber, Seied Saeid" uniqKey="Esmaeili Saber S" first="Seied Saeid" last="Esmaeili Saber">Seied Saeid Esmaeili Saber</name><name sortKey="Godazi, Mohammadreza" sort="Godazi, Mohammadreza" uniqKey="Godazi M" first="Mohammadreza" last="Godazi">Mohammadreza Godazi</name><name sortKey="Karimy, Mahmood" sort="Karimy, Mahmood" uniqKey="Karimy M" first="Mahmood" last="Karimy">Mahmood Karimy</name><name sortKey="Koohestani, Hamid Reza" sort="Koohestani, Hamid Reza" uniqKey="Koohestani H" first="Hamid Reza" last="Koohestani">Hamid Reza Koohestani</name><name sortKey="Montazer, Reza" sort="Montazer, Reza" uniqKey="Montazer R" first="Reza" last="Montazer">Reza Montazer</name><name sortKey="Roustaei Shirdel, Aboulfazl" sort="Roustaei Shirdel, Aboulfazl" uniqKey="Roustaei Shirdel A" first="Aboulfazl" last="Roustaei Shirdel">Aboulfazl Roustaei Shirdel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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